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| TINNICAR - Caroverine Hydrochloride Capsules |
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| Description | ||||||||||||||||||
| Caroverine a transmitter antagonist is a quinoxaline derivative i.e. 1-(diethyl amino ethyl)-3-(p-methoxy-benzyl)-1, 2-dihydro quinoxaline-2-on. (C22H27N3O2) it belongs to a Papaverine group as it is structurally similar. It is hypothesized that glutamate is known to be the important neurotransmitter in the CNS & the signals between the IHC (Inner Hair Cell) & the cochlear afferent Neuron fibers are most likely to be transmitted by glutamate. Caroverine is a glutamate receptor antagonist & also has other activities, which reduces the excitability of the nerve cell function. These activities include calcium antagonism & potential repair gene inducer. In addition caroverine penetrates CSF & reaches inner ear fluids. | ||||||||||||||||||
| Mechanism of Action | ||||||||||||||||||
Excessive glutamate when binds to NMDA receptors, the receptor opens & allows calcium & sodium to enter the neuron, abnormal levels of calcium disturbs ionic balance causing spontaneous depolarization state, Pathological spontaneous depolarization state is reversed back to physiological polarization state by antagonistic property of Caroverine. Caroverine is Oto-neuroprotective(inner ear protective) agent. It acts as an N-type calcium channel blocker, competitive AMPA (2-amino-3-(5-methyl-3-oxo-1, 2- oxazol-4-yl) propanoic acid) receptor antagonist, and non-competitive NMDA (N-methyl D-asparate) receptor antagonist. It also has potent antioxidant effects. |
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| Indications | ||||||||||||||||||
| In Cochlear Synaptic Tinnitus | ||||||||||||||||||
| Dosage | ||||||||||||||||||
| Two Capsules twice a day for 3 to 6 months or as directed by physician. | ||||||||||||||||||
| Contraindications | ||||||||||||||||||
| Hypersensitivity to Caroverine, acute stomach & intestinal ulcers. | ||||||||||||||||||
| Precautions | ||||||||||||||||||
| In case of Gastritis, liver damage & in case of acute voiding disorder. | ||||||||||||||||||
| Storage | ||||||||||||||||||
| Store in a Cool & dry place. | ||||||||||||||||||
| Presentation | ||||||||||||||||||
| Tinnicar is available in a strip of 10 capsules (alu-alu packing). | ||||||||||||||||||